{"product_id":"mycofold-rhu-pdgf-bb","title":"MycoFold™ rHu PDGF-BB","description":"\u003cp class=\"MsoNormal\"\u003eMycoFold™ Recombinant Human Platelet-Derived Growth Factor Subunit B (rHu PDGF-BB) is a growth factor that plays an essential role in regulating embryonic development, cell proliferation, migration, survival, and chemotaxis.  This protein is a potent mitogen that stimulates the proliferation of cells of mesenchymal origin, such as fibroblasts, smooth muscle cells, and pericytes, and promotes cell survival by activating anti-apoptotic signaling pathways.  PDFG-BB has the broadest receptor binding profile among the PDGF isoforms, allowing it to activate all three receptor dimeric combinations (PDGFR\u003cspan style=\"font-size: 12.0pt; line-height: 115%; font-family: Symbol; mso-fareast-font-family: Aptos; mso-fareast-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\"\u003eaa\u003c\/span\u003e, PDGFR\u003cspan style=\"font-size: 12.0pt; line-height: 115%; font-family: Symbol; mso-fareast-font-family: Aptos; mso-fareast-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\"\u003eab\u003c\/span\u003e, and PDGFR\u003cspan style=\"font-size: 12.0pt; line-height: 115%; font-family: Symbol; mso-fareast-font-family: Aptos; mso-fareast-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\"\u003ebb\u003c\/span\u003e).  Once the receptor is activated, numerous intracellular cascades are triggered, including PI3K\/AKT\/mTOR, MAPK, PLC\u003cspan style=\"font-size: 12.0pt; line-height: 115%; font-family: Symbol; mso-fareast-font-family: Aptos; mso-fareast-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\"\u003eg\u003c\/span\u003e, JAK\/STAT, RHO GTPase, CRKL\/C3G\/RAP1, and others, which lead to cell proliferation, migration, and survival. PDGF-BB binding leads to upregulation of transcription factors and genes, including (i) cMyc, c-Fos, c-Jun (proliferation), (ii) NF-kB (survival and inflammation), (iii) HIF\u003cspan style=\"font-size: 12.0pt; line-height: 115%; font-family: Symbol; mso-fareast-font-family: Aptos; mso-fareast-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\"\u003ea\u003c\/span\u003e (angiogenesis), and (iv) Cyclin D1 (cell cycle progression).\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003eProtein is an antiparallel, disulfide-linked homodimer (12.3 kDa) expressed via extracellular secretion of K. phaffii engineered yeast.  Chaperone-guided folding and engineered secretion pathways generate native tertiary 3D structures, thereby optimizing thermostability.  Priced for best-in-class bioactivity value (IUs\/mg\/$) to maximize research budgets.\u003cbr\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cb\u003e\u003cu\u003eKey Research Applications\u003c\/u\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cul type=\"disc\" style=\"margin-top: 0in;\"\u003e\n\u003cli style=\"margin-bottom: 4.0pt; line-height: normal; mso-list: l0 level1 lfo1; tab-stops: list .5in;\" class=\"MsoNormal\"\u003eDifferentiation of oligodendrocyte precursors and mesenchymal stem cells (MSCs)\u003c\/li\u003e\n\u003cli style=\"margin-bottom: 4.0pt; line-height: normal; mso-list: l0 level1 lfo1; tab-stops: list .5in;\" class=\"MsoNormal\"\u003eBlood-brain barrier (BBB) integrity due to pericyte loss due to impaired PDGF-BB signaling\u003c\/li\u003e\n\u003cli style=\"margin-bottom: 4.0pt; line-height: normal; mso-list: l0 level1 lfo1; tab-stops: list .5in;\" class=\"MsoNormal\"\u003eCell proliferation and control stimulus of fibroblasts, smooth muscle cells, and pericytes\u003c\/li\u003e\n\u003cli style=\"margin-bottom: 4.0pt; line-height: normal; mso-list: l0 level1 lfo1; tab-stops: list .5in;\" class=\"MsoNormal\"\u003eOsteoblast and chondrocyte proliferation and differentiation\u003c\/li\u003e\n\u003cli style=\"margin-bottom: 4.0pt; line-height: normal; mso-list: l0 level1 lfo1; tab-stops: list .5in;\" class=\"MsoNormal\"\u003eTumor stroma formation and the role of cancer-associated fibroblasts\u003c\/li\u003e\n\u003cli style=\"margin-bottom: 4.0pt; line-height: normal; mso-list: l0 level1 lfo1; tab-stops: list .5in;\" class=\"MsoNormal\"\u003eAutocrine and paracrine PDGF-BB signaling in tumor progression\u003c\/li\u003e\n\u003cli style=\"margin-bottom: 4.0pt; line-height: normal; mso-list: l0 level1 lfo1; tab-stops: list .5in;\" class=\"MsoNormal\"\u003eTissue repair and molecular mechanisms of granulation tissue formation in wound healing and regenerative medicine.\u003c\/li\u003e\n\u003cli style=\"margin-bottom: 4.0pt; line-height: normal; mso-list: l0 level1 lfo1; tab-stops: list .5in;\" class=\"MsoNormal\"\u003eBiomaterial research incorporating hydrogels and or scaffolds to promote tissue regeneration.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"My Store","offers":[{"title":"10 µg","offer_id":47304503853211,"sku":"GR1002-10","price":130.0,"currency_code":"USD","in_stock":true},{"title":"50 µg","offer_id":47304541864091,"sku":"GR1002-50","price":326.0,"currency_code":"USD","in_stock":true},{"title":"100 µg","offer_id":47304503885979,"sku":"GR1002-100","price":542.0,"currency_code":"USD","in_stock":true},{"title":"250 µg","offer_id":47304503918747,"sku":"GR1002-250","price":1096.0,"currency_code":"USD","in_stock":true},{"title":"500 µg","offer_id":47304503951515,"sku":"GR1002-500","price":1880.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":47304503984283,"sku":"GR1002-1000","price":3122.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0724\/6318\/8123\/files\/Vial_Image_GR1002_rHu_PDGFBB_NewBackground.jpg?v=1771439160","url":"https:\/\/mycofold.com\/products\/mycofold-rhu-pdgf-bb","provider":"MycoFold","version":"1.0","type":"link"}