{"product_id":"mycofold-ai™-hyperstable-rhu-epidermal-growth-factor-egf","title":"MycoFold-AI™ Hyperstable rHu Epidermal Growth Factor (EGF)","description":"\u003cp\u003e\u003cspan lang=\"EN-CA\"\u003eMycoFold-AI™ Hyperstable rHu EGF is a proprietary engineered variant of human epidermal growth factor, equivalent in length to the 53-residue wild-type mature domain and engineered for improved thermostability, increased EGFR binding affinity and higher expression titre relative to the wild-type sequence.  The specific substitutions are proprietary; the wild-type properties below are provided as reference.  \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan lang=\"EN-CA\"\u003eWild-type EGF is a potent mitogen for cells of epithelial, mesenchymal and neural origin, driving proliferation, migration and survival, and is one of the most widely used growth factors in cell culture, serving as a core component of media for keratinocytes, epithelial cells, organoids, neural stem cells and induced pluripotent stem cells.  It is generated by proteolytic release of a 53-residue domain from a large membrane-anchored precursor, pro-epidermal growth factor, and adopts a compact two-subdomain fold built around three conserved disulfide bonds and a central antiparallel beta-sheet, the architecture that defines the EGF-like domain family.  \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan lang=\"EN-CA\"\u003eSignaling upregulates transcriptional programs governing (i) cell cycle entry and proliferation via MYC, FOS, JUN and cyclin D1, (ii) survival via PI3K\/AKT and BCL-2 family members, (iii) epithelial migration and wound repair via RAC1 and cytoskeletal remodelling, and (iv) STAT-dependent transcription.  Wild-type EGF is expressed at high levels in salivary gland, kidney and pancreas, and is abundant in saliva, urine, milk and plasma.\u003c\/span\u003e\u003c\/p\u003e","brand":"My Store","offers":[{"title":"10 µg","offer_id":49625998196891,"sku":"GR1009-10","price":8.0,"currency_code":"USD","in_stock":true},{"title":"50 µg","offer_id":49625998229659,"sku":"GR1009-50","price":40.0,"currency_code":"USD","in_stock":true},{"title":"100 µg","offer_id":49625998262427,"sku":"GR1009-100","price":80.0,"currency_code":"USD","in_stock":true},{"title":"500 µg","offer_id":49625998295195,"sku":"GR1009-500","price":187.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":49625998327963,"sku":"GR1009-1000","price":239.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0724\/6318\/8123\/files\/MycoFold_GR1009_EGFAI_lab_scene.png?v=1790198675","url":"https:\/\/mycofold.com\/products\/mycofold-ai%e2%84%a2-hyperstable-rhu-epidermal-growth-factor-egf","provider":"MycoFold","version":"1.0","type":"link"}