{"product_id":"mycofold™-rhu-granulocyte-macrophage-colony-stimulating-factor-gm-csf","title":"MycoFold™ rHu Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF)","description":"\u003cp\u003e\u003cspan lang=\"EN-CA\"\u003eThis cytokine is a haematopoietic growth factor that drives the survival, proliferation and differentiation of granulocyte and macrophage progenitor cells, and functions as a terminal differentiation and activation signal for mature myeloid cells.  \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan lang=\"EN-CA\"\u003eGM-CSF is produced by activated T cells, macrophages, endothelial cells, fibroblasts and mast cells rather than being constitutively expressed, positioning it as an inducible emergency haematopoiesis signal rather than a steady-state one.  It promotes the differentiation of monocytes into dendritic cells and inflammatory macrophages, primes neutrophils and eosinophils, and is a standard component of media for the ex vivo generation of monocyte-derived dendritic cells and macrophages.  \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan lang=\"EN-CA\"\u003eSignalling through the GM-CSF receptor upregulates transcriptional programmes governing (i) cell cycle entry and proliferation via STAT5 and cyclin D, (ii) survival via BCL-2 family members and PI3K\/AKT, (iii) myeloid lineage commitment via PU.1 and IRF factors, and (iv) inflammatory effector function via NF-kB.  The protein adopts a compact four-helix bundle fold of the short-chain class of the haematopoietin cytokine family, stabilised by two intrachain disulfide bonds.\u003c\/span\u003e\u003c\/p\u003e","brand":"My Store","offers":[{"title":"10 µg","offer_id":49624992153755,"sku":"GR1006-10","price":129.0,"currency_code":"USD","in_stock":true},{"title":"50 µg","offer_id":49624992186523,"sku":"GR1006-50","price":313.0,"currency_code":"USD","in_stock":true},{"title":"100 µg","offer_id":49624992219291,"sku":"GR1006-100","price":519.0,"currency_code":"USD","in_stock":true},{"title":"500 µg","offer_id":49624992252059,"sku":"GR1006-500","price":1561.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":49624992284827,"sku":"GR1006-1000","price":2604.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0724\/6318\/8123\/files\/MycoFold_GR1006_GMCSF_lab_scene.png?v=1790188574","url":"https:\/\/mycofold.com\/products\/mycofold%e2%84%a2-rhu-granulocyte-macrophage-colony-stimulating-factor-gm-csf","provider":"MycoFold","version":"1.0","type":"link"}